Sex-Based Animal Model Studies Identifying Effective Therapeutics for Treatment-Resistant Depression at Altitude

Title: Sex-Based Animal Model Studies Identifying Effective Therapeutics for Treatment-Resistant Depression at AltitudePresenter: Rob Ettaro, MSContributors: Shami Kanekar, PhD (University of Utah); M.D. Hoffman (University of Utah); P.F. Renshaw (University of Utah)Faculty Sponsor: Shami Kanekar, PhD (University of Utah)Date: 5/12/21Brief Description: Discussing sex-based animal model studies that identify effective treatments for treatment-resistant depression at altitudeKeywords/Main Subjects: Sex-based animal models, treatment-resistant depression, depression, …

Methamphetamine Rewards and Brain Dopamine May Increase with Housing at Moderate Altitude in Females: Sex-Based Animal Model Studies

Title: Methamphetamine Rewards and Brain Dopamine May Increase with Housing at Moderate Altitude in Females- Sex-Based Animal Model StudiesPresenter: Shami Kanekar, PhD, University of Utah School of MedicineDate: 5/12/21Brief Description: Discussing whether living at altitude poses a biological risk for meth abuseKeywords/Main Subjects: Animal model studies, dopamine, meth use at altitude, Copyright: copyright Shami Kanekar ©2021Contact: Shami.Kanekar@hsc.utah.edu Q&A: https://youtu.be/qFPrzUVE8CY?t=13836

Therapeutics Targeting Brain Bioenergetics may be Effective as Antidepressants in Altitude-related Treatment-Resistant Depression: Sex-based Animal Model Studies

Title: Therapeutics Targeting Brain Bioenergetics may be Effective as Antidepressants in Altitude-related Treatment-Resistant Depression: Sex-based Animal Model StudiesPresenter: Shami Kanekar, PhD, University of Utah Department of Psychiatry and VISN19 Rocky Mountain MIRECC & US Department of Veterans AffairsContributors: H.J. Ombach (University of Utah Department of Psychiatry), J. Brown (University of Utah Department of Psychiatry), M.D. Hoffman …

The Impact of Living at Altitude on Depression and Anti-depressant Function in Utah Women: The Need for Novel Antidepressants

Objectives: Utah has the highest rates of depression and suicide in the US, despite high rates of antide-pressant prescriptions. People living at altitude are exposed to chronic hypobaric hypoxia, which may disrupt brain serotonin and bioenergetic function, to worsen depression and reduce selective serotonin reuptake inhibitor (SSRI) function …