The Impact of Living at Altitude on Depression and Anti-depressant Function in Utah Women: The Need for Novel Antidepressants

Objectives: Utah has the highest rates of depression and suicide in the US, despite high rates of antide-pressant prescriptions. People living at altitude are exposed to chronic hypobaric hypoxia, which may disrupt brain serotonin and bioenergetic function, to worsen depression and reduce selective serotonin reuptake inhibitor (SSRI) function …